Medications are the most widely utilized interventions in health care, and medication-related harm constitutes the greatest proportion of the total preventable harm due to unsafe care, let alone the economic and psychological burden imposed by such harm. Acknowledging this substantial burden and recognizing the complexity of medication-related harm prevention and reduction, "Medication Safety" has been selected as the theme for World Patient Safety Day 2022.

The campaign is envisaged to provide the needed impetus to consolidate the efforts of the existing WHO Global Patient Safety Challenge: Medication Without Harm, emphasizing the need to adopt a systems approach and promote safe medication practices to prevent medication errors and reduce medication-related harm. Special consideration will be given to areas where most harm occurs. The key action areas are high-risk situations, transitions of care, and polypharmacy.